Host Metabolic Disorders Induced by Alterations in Intestinal Flora under Dietary Pesticide Exposure

A dietary pesticide residue causes
underestimated influences on
body health. In this work, experimental mice were exposed to commonly
used pesticides that cause insulin resistance, inflammation, and non-alcoholic
fatty liver diseases. Alterations in intestinal flora were detected
in the exposure groups. The abundance of the flora causing high endotoxin
production was intensively increased and led to body inflammation.
High Firmicutes/Bacteroidetes and obesity-related flora characteristics
were also found. The metabolisms of intestinal flora and host circulation
were investigated through metabolomics. The associations of flora
with their metabolites and host circulation were also established.
Association analysis can determine the influences of pesticide exposure
on such a complex system. The affected metabolic pathways in the liver
were also determined to clarify the mechanism underlying the effect
of pesticide exposure on host physiology. Interventions with fructooligosaccharides
and fecal microbiota transplantation alleviated the metabolic disorders,
thus directly confirming that the intestinal flora mediates the effects
of pesticide exposure on host circulation. This work elucidated the
intestinal-flora-mediated effects of dietary pollutant exposure on
body health and provided potential measures for regulating flora and
host circulation.