Table S1 - Human Biodistribution and Dosimetry of 11C-CUMI-101, an Agonist Radioligand for Serotonin-1A Receptors in Brain

The effective dose for 11C-CUMI-101 was 5.3±0.5 microSv/MBq (19.5±2.2 mrem/mCi), which is comparable to other 11C-labeled ligands for brain imaging. Among 33 other 11C-radioligands used for brain imaging, the mean effective dose was 5.5±2.0, with range of 3.0 to 16.0. The peak brain uptake for 11C-CUMI-101 was 11% injected activity (IA), the highest relative to more than 20 other radioligands used for brain imaging. (DOCX)