Inter-strain Heterogeneity in Responses to TCDD

We profiled hepatic transcriptional responses of 6 strains of rats with varying sensitivity to a dioxin, TCDD, at 19 hours following exposure. The resistant rats exhibited significantly reduced transcriptional responses in comparison to the sensitive strains. We hypothesize that genes which show differential changes between the resistant and sensitive rats may potentially explain sensitivity.本研究对6种对二噁英（TCDD）敏感性存在差异的大鼠品系，在暴露19小时后的肝脏转录应答情况进行了表征。与敏感品系大鼠相比，抗性大鼠的转录应答水平显著降低。本研究推测，在抗性与敏感大鼠之间呈现差异变化的基因，或可解释大鼠对该物质的敏感性差异。