Single-Cell Trajectories of Melanoma Cell Resistance to Targeted Treatment
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP301922
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资源简介：
In order to identify mechanisms of melanoma treatment resistance, we applied micorofluidic scRNA-Seq to the transcripomes of a total of about 31,000 single cells obtained form A375 melanoma cell line untreated/sensitive or treated with BRAF inhibitor vemurafenib, either alone or in combination with MEK1 inihibitor cobimetinib or trametinib. Analysis by dimensionality reduction software tSNE and SOM identified a clonal heterogeneity clearly seperating all 4 possible treatment conditions. Overall design: scRNA-Seq of BRAF-mutant A375 cells in 4 treatment conditions: untreated/sensitive cells, cells resistant to vemurafenib, cells double-resistant to vemurafenib and cobimetinib, cells double-resistant to vemurafenib and trametinib
创建时间：
2023-01-25
