Comprehensive genome analysis of major Staphylococcus specieas. Staphylococcus

The genus Staphylococcus has been recognised as commensals colonizing the skin and mucous membranes of some mammals and birds. Some of these species have a clear clinical and economic relevance, as they are a frequent cause of infection in humans, livestock, and domestic animals. Although the genus is well known for the human opportunist pathogen Staphylococcus aureus, which is famous worldwide major human pathogen and its infection lead a cause of various clinical symptoms including bacteremia and infective endocarditis, there are some other species such as S. epidermidis, S. lugdunesis, S. saprophyticus and S. schleiferi that have been also associated with human infections. In this study, we determine the complete genome sequences of major Staphylococcus species and performed comprehensive genome analysis to reveal the evolutionary process with detailed genome properties and genetic factors for host adaptation in these species.