TP53 stimulates CDKN1A (p21) transcription

Binding of TP53 (p53) to its response elements in the promoter of the CDKN1A (p21) gene stimulates CDKN1A transcription (El-Deiry et al. 1993). Binding of ZNF385A (HZF) to the DNA binding domain of TP53 facilitates CDKN1A induction and the consequent cell cycle arrest (Das et al. 2007).

TP53（p53）与其响应元件结合，促进CDKN1A（p21）基因启动子区的转录（El-Deiry等，1993年）。ZNF385A（HZF）与TP53的DNA结合域结合，有利于CDKN1A的诱导及随之而来的细胞周期阻滞（Das等，2007年）。