DRB1 risk and protective residues for specific autoantibodies.

Significant positions map overwhelmingly to Class II proteins, primarily DRB1 for nRNP, Ro/La and cardiolipin, and DPB1 for Sm. Positions with significant association have the most-risk and most-protective amino acids shown. Residues written as: position, amino acid, position in binding pocket, P-value for the Korean and Han Chinese samples, odds ratio. Side-chains predicted risk include: F, L, D. R and S are predicted to be protective. Residues are formatted according to their consistency with the statistical SLE risk-prediction model: risk (bold); protective (italics); and neither (unformatted).