Rad51

Enables DNA strand exchange activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in DNA metabolic process. Acts upstream of or within several processes, including DNA metabolic process; cellular response to hydroxyurea; and chromosome organization. Located in chromosome; cytoplasm; and male germ cell nucleus. Is active in site of double-strand break. Is expressed in several structures, including brain; compacted morula; gonad; hemolymphoid system; and paravertebral ganglion. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Nov 2024]

本数据集包含具备DNA链交换活性、染色质结合活性和单链DNA结合活性的基因；该基因参与DNA代谢过程，并在包括DNA代谢过程、细胞对羟脲的响应以及染色体组织在内的多个过程中发挥作用。该基因位于染色体、细胞质和雄性生殖细胞核中，在双链断裂的位点活跃表达。其在多个结构中表达，包括大脑、紧密的桑椹胚、性腺、血淋巴系统和副神经节。该基因的人类同源基因与范可尼贫血补体组R、乳腺癌、先天性镜像运动障碍和卵巢癌有关。与人类RAD51（RAD51重组酶）同源。[由基因组资源联盟提供，2024年11月]