Ventral midbrain-type neural stem/precursor cells (VM-NSCs) derived from human midbrain organoids as a stable source for treating symptoms of Parkinson’s disease

In this study, midbrain-like organoids were yielded from hPSCs to prepare cells used for PD therapy. Neural stem/precursor cells (NSCs) isolated from midbrain organoids (Og-NSCs) expanded stably and differentiated into mDA neurons, and an unprecedentedly high proportion express midbrain-specific factors. mRNA profile of 2D culture system derived NSCs, Midbrain Organoid derived NSCs, Midbrain-like organoids. GSM4039143 and GSM4039144 are included in this article as PD ips 2D-NSC samples.