Sin3a regulates epithelial progenitor cell fate during lung development

Comparison of global transcription profiles in mouse E12.5 embryonic lung from Shh-Cre;Sin3a flox/+ control with Shh-Cre;Sin3a flox/flox revealed a large change genes due to loss of Sin3a in early lung development. Examination of 2 different transcriptomes in 2 genotypes with three replicates.对Shh-Cre;Sin3a flox/+ 对照小鼠与Shh-Cre;Sin3a flox/flox 小鼠的胚胎发育第12.5天（E12.5）肺组织的全局转录谱进行比较分析，结果显示：在肺脏早期发育进程中，Sin3a基因的缺失会引发大量基因表达的显著改变。本研究针对两种基因型的样本各设置三次生物学重复，完成了两套转录组的检测与分析。