OFC5: Meta GWAS Analysis of OFC1 and OFC4

**[Link to project pages of OFC5: Meta GWAS Analysis of OFC1 and OFC4](http://www.facebase.org/hgai/OFC5.html)** This project is a genome-wide meta-analyses of cleft lip with or without palate (CL/P), cleft palate alone (CP), and all orofacial clefts (OFCs) across two large, multiethnic studies, [GENEVA OFC](/hgai/OFC1.html) and [POFC](/hgai/OFC4.html), both of which can be explored through our Human GenomicsAnalysis Interface. For information about access to individual level data via dbGaP, study investigators and funding sources, please see the respective pages of the two original projects, [GENEVA OFC](/hgai/OFC1.html) and [POFC](/hgai/OFC4.html). The goal of this study is to identify additional genetic risk variants for OFCs, considering the historical groupings of CL/P and CP, but also exploring the possibility of shared etiology. Therefore, we conducted genome-wide meta-analyses for CL/P, CP, and all OFCs, drawing from the two of the largest CL/P studies published to date and the two published CP studies. In addition to the combined analysis of the two multiethnic study populations, we also conducted population specific meta-analyses in sub-samples of Asian and European ancestry. A total of 412 individuals, who were common to both the GENEVA OFC and POFC studies were excluded from the GWASs of the GENEVA OFC study for this analysis prior to meta-analysis. Click [here](/hgai/OFC5.html) to access the data and results for this dataset.