Genes regulated by nuclear calcium signaling in hippocampal neurons.

Underlined genes have a putative role in cell death/cell survival based on information obtained using Gene Ontology (GO) analysis with the GO term ‘Apoptosis’ or literature searches. AID genes analyzed in this study are boxed. ID, GenBank ID. ACT/REP, activation/repression by action potential bursting. The fold changes compared to control in probe set expression are indicated as follows: significantly induced with fold changes between 2 and 5 (+), between 5 and 10 (++), and more than 10 (+++); significantly reduced with fold changes between 2 and 5 (−), between 5 and 10 (−−), and more than 10 (−−−). INH, percentage of inhibition of activation/repression by blockade of nuclear calcium signaling with CaMBP4 as indicated as follows: inhibition between 40 and 60% (*), between 60 and 80% (**), and more than 80% (***). Time point of analysis was 4 hours after induction of action potential bursting using bicuculline except for Btg2 for which the time point for the fold induction given was 2 hours after induction of action potential bursting using bicuculline [6]. Ref. indicates that the data presented were from [6].