Faecal bacteriome and metabolome in paediatric Crohn's disease

Treatment by anti-TNF-alpha antibodies (anti-TNF) is known to change the dysbiotic faecal bacteriome in Crohn's disease (CD). However, it has not been explored whether these changes are solely due to decreasing mucosal inflammatory activity or whether similar bacteriome reactions may also be observed in gut-healthy subjects on anti-TNF treatment. Here we aim to characterise faecal bacteriome and metabolite changes upon anti-TNF administration in children with CD and contrast those to the effects in anti-TNF-treated children with juvenile idiopathic arthritis.