Intravascular volume parameters.

For the investigation of fluid responsive parameters were calculated: relative stroke volume (rSV) characterized by the area under the arterial blood pressure curve, systolic pressure variation (SPV), relative stroke volume variation (rSVV), and pulse pressure variation (PPV). No NS1619-dependent effect on these parameters was discovered. Data obtained after inhalation were subtracted from individual basis values and individual value differences (Δ) were calculated for each animal and time point.