Engineering of stable and fast-folding sequences of model proteins.
收藏PubMed Central1993-08-01 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC47103/
下载链接
链接失效反馈官方服务：
资源简介：
The statistical mechanics of protein folding implies that the best-folding proteins are those that have the native conformation as a pronounced energy minimum. We show that this can be obtained by proper selection of protein sequences and suggest a simple practical way to find these sequences. The statistical mechanics of these proteins with optimized native structure is discussed. These concepts are tested with a simple lattice model of a protein with full enumeration of compact conformations. Selected sequences are shown to have a native state that is very stable and kinetically accessible. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-08-01
