LIFR antagonism reverses epithelial pro-CAF programs in pancreatic ductal adenocarcinoma
收藏Mendeley Data2026-04-09 收录
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In PDAC cancer cells, MIAPaCa-2 cells, LIF induced a coordinated transcriptional network encompassing inflammatory mediators, paracrine fibroblast-activating signals and ECM/mechanotransductive modules, while repressing stromal-inhibitory genes. These signatures were recapitulated in PDAC tissues, where LIF expression directly correlated with CAF, iCAF and myCAF markers and with stromal remodelling genes.
提供机构：
Universita degli Studi di Perugia Dipartimento di Medicina
