National Sleep Research Resource (NSRR): Cleveland Family Study (CFS)

The [Cleveland Family Study (CFS)](https://sleepdata.org/datasets/cfs) is a family-based study of sleep apnea, consisting of 2,284 individuals (46% African American) from 361 families studied on up to 4 occasions over a period of 16 years. The study began in 1990 with the initial aims of quantifying the familial aggregation of sleep apnea. National Institutes of Health (NIH) renewals provided expansion of the original cohort, including increased minority recruitment, and longitudinal follow-up, with the last exam occurring in February 2006. The [CFS](https://sleepdata.org/datasets/cfs) was designed to provide fundamental epidemiological data on risk factors for sleep disordered breathing (SDB). The sample was selected by identifying affected probands who had laboratory diagnosed obstructive sleep apnea. All first-degree relatives, spouses and available second-degree relatives of affected probands were studied. In addition, during the first 5 study years, neighborhood control families were identified through a neighborhood proband, and his/her spouses and first-degree relatives. Each exam, occurring at approximately 4-year intervals, included new enrollment as well as follow up exams for previously enrolled subjects. For the first three visits, data, including an overnight sleep study, were collected in participants' homes while the last visit occurred in a general clinical research center (GCRC). Phenotypic characterization of the entire cohort included overnight sleep apnea studies, blood pressure, spirometry, anthropometry and questionnaires. Currently, data of 710 individuals are available for use through [BioData Catalyst](https://biodatacatalyst.nhlbi.nih.gov/) (with genotype data available through [dbGaP](https://www.ncbi.nlm.nih.gov/gap/)).

The [National Sleep Research Resource](https://sleepdata.org/) (NSRR) is a NIH-supported sleep data repository that offers free access to large collections of de-identified physiological signals and related clinical data from a large range of cohort studies, clinical trials and other data sources from children and adults, including healthy individuals from the community and individuals with known sleep or other health disorders. The goals of [NSRR](https://sleepdata.org/) are to facilitate rigorous research that requires access to large or more diverse data sets, including raw physiological signals, to promote a better understanding of risk factors for sleep and circadian disorders and/or the impact of sleep disturbances on health-related outcomes. Data from over 15 data sources and more than 40,000 individual sleep studies, many linked to dozens if not hundreds of clinical data elements, are available (as of Feb. 2022). Query tools are available to identify variables of interest, and their meta-data and provenance.

[克利夫兰家庭研究（Cleveland Family Study, CFS）](https://sleepdata.org/datasets/cfs)是一项针对睡眠呼吸暂停（sleep apnea）的家庭队列研究，共纳入361个家庭的2284名受试者（其中46%为非裔美国人），在16年的随访周期内最多完成4次检测。该研究于1990年启动，初始目标为量化睡眠呼吸暂停的家族聚集性。美国国立卫生研究院（National Institutes of Health, NIH）的后续资助项目扩展了原始队列，包括增加少数族裔招募规模并开展纵向随访，最后一次检测于2006年2月完成。CFS旨在为睡眠呼吸障碍（sleep disordered breathing, SDB）的危险因素提供基础流行病学数据。该队列通过筛选经实验室确诊为阻塞性睡眠呼吸暂停（obstructive sleep apnea）的先证者进行招募，随后纳入所有先证者的一级亲属、配偶及可获取的二级亲属。此外，在研究的前5年，还通过社区先证者及其配偶、一级亲属招募了社区对照家庭。每次检测间隔约4年，既包含新受试者入组，也为已入组受试者提供随访检测。前三次检测均在受试者家中完成，采集包括夜间睡眠监测在内的相关数据；最后一次检测则在通用临床研究中心（general clinical research center, GCRC）内开展。对整个队列的表型表征包括夜间睡眠呼吸暂停监测、血压测量、肺量测定、人体测量以及问卷调查。目前，已有710名受试者的数据可通过[生物数据催化平台（BioData Catalyst）](https://biodatacatalyst.nhlbi.nih.gov/)获取，其中基因型数据可通过[基因组与表型数据库（dbGaP）](https://www.ncbi.nlm.nih.gov/gap/)获取。

[国家睡眠研究资源库（National Sleep Research Resource, NSRR）](https://sleepdata.org/)是由美国国立卫生研究院资助的睡眠数据存储库，面向公众免费提供来自多类队列研究、临床试验及其他数据源的去标识化生理信号与相关临床数据，涵盖儿童与成人群体，包括社区健康个体以及已确诊睡眠障碍或其他健康疾病的受试者。NSRR的目标是推动需要大规模或多样化数据集（包括原始生理信号）的严谨研究，以加深人们对睡眠及昼夜节律紊乱危险因素，或睡眠障碍对健康相关结局影响的理解。截至2022年2月，该资源库已收录超过15个数据源的4万余份独立睡眠研究数据，其中多数数据关联了数十乃至上百项临床数据元素。平台提供查询工具，用于检索目标变量及其元数据与来源信息。