Integrated multi-omics reveals Enterococcus faecalis JM263 alleviates high-concentrate diet-induced hepatic injury via the gut-liver axis in goats

This dataset contains raw liquid chromatography-tandem mass spectrometry (LC-MS/MS) data derived from the liver tissues of goats (Capra hircus). The purpose of this study is to explore the metabolic regulatory mechanism of the probiotic Enterococcus faecalis JM263 in goats fed a high-concentrate diet (HCD). Experimental Design Feeding experiments were conducted on yaks, divided into two groups: 1) Control group, fed a high-concentrate diet; 2) Treatment group, fed the same HCD supplemented with Enterococcus faecalis JM263. After intervention, liver tissues were collected, and metabolomic analysis was performed following quenching and extraction. Objectives Untargeted metabolomics was used to identify differential metabolites and enriched pathways related to the hepatoprotective effect of the probiotic. This dataset supports the findings regarding the gut-liver axis interaction in ruminants under dietary stress.