Webb2002 - Fas/FasL mediated tumor T-cell interaction

Webb2002 - Fas/FasL mediated tumor T-cell interaction
This deterministic model of
immunological surveillance involving tumour cell–T-lymphocyte
interaction, cell surface expression of Fas/FasL, and their
secreted soluble forms.

This model is described in the article:

Cells behaving badly: a
theoretical model for the Fas/FasL system in tumour
immunology.

Webb SD, Sherratt JA, Fish RG.
Math Biosci 2002 Sep-Oct; 179(2):
113-129
Abstract:

One proposed mechanism of tumour escape from immune
surveillance is tumour up-regulation of the cell surface ligand
FasL, which can lead to apoptosis of Fas receptor (Fas)
positive lymphocytes. Based upon this 'counterattack', we have
developed a mathematical model involving tumour cell-lymphocyte
interaction, cell surface expression of Fas/FasL, and their
secreted soluble forms. The model predicts that (a) the
production of soluble forms of Fas and FasL will lead to the
down-regulation of the immune response; (b) matrix
metalloproteinase (MMP) inactivation should lead to increased
membrane FasL and result in a higher rate of Fas-mediated
apoptosis for lymphocytes than for tumour cells. Recent studies
on cancer patients lend support for these predictions. The
clinical implications are two-fold. Firstly, the use of broad
spectrum MMP inhibitors as anti-angiogenic agents may be
compromised by their adverse effect on tumour FasL
up-regulation. Also, Fas/FasL interactions may have an impact
on the outcome of numerous ongoing immunotherapeutic trials
since the final common pathway of all these approaches is the
transduction of death signals within the tumour cell.

This model is hosted on
BioModels Database
and identified by:
BIOMD0000000661.
To cite BioModels Database, please use:
Chelliah V et al. BioModels: ten-year
anniversary. Nucl. Acids Res. 2015, 43(Database
issue):D542-8.

To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
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