Endothermy is an evolutionary innovation in Eutherian mammals and birds. In Eutherian mammals, UCP1 is a key protein in adaptive nonshivering thermogenesis. Although ucp1 arose early in the vertebrate
ABSTRACT New treatments proposed for patients with Duchenne muscular dystrophy (DMD) have their efficacy evaluated by lower limb tests. However, upper limb function tests evaluate both ambulatory (A)
Using a hybrid computational-biochemical approach, we have demonstrated the endogenous presence of a large and sequence diverse class of orphan, blood-borne peptides that we call “capped peptides.” Ca
Animals native to the hypoxic and cold environment at high altitude provide an excellent opportunity to elucidate the integrative mechanisms underlying the adaptive evolution of complex traits. The ca
