Impact of Mint3 on transcriptome in MDA-MB-231 tumors

Owing to the lack of therapeutic targets, chemotherapy with cytotoxic drugs is the general treatment for triple-negative breast cancer (TNBC). However, most TNBCs acquire resistance to chemotherapy, thereby lowering the therapeutic outcome. In addition to oncogenic mutations in TNBC, microenvironment-induced mechanisms render chemoresistance more complex and robust in vivo. Here, we aimed to analyze whether depletion of Munc18-1 interacting protein 3 (Mint3), which activates hypoxia-inducible factor 1 (HIF-1) during normoxia, sensitizes TNBC to chemotherapy.