Predictions for STDP curves at CA3-CA1 synapses under the triplet protocol for a gradient of inter-pairing frequencies in the theta band (and lower).

(A) 75 pairings at produced latency-dependent LTD-only curves. (B) Temporally symmetric, bidirectional STDP was supported by frequencies from 4 Hz to 10 Hz ( as defined in Figure 4). At 11 Hz, LTP is saturated for all latencies (horizontal black). Darker curves correspond to higher frequencies (see panel legend).