Structural diversity and anti-lung cancer activity evaluation of two Co(II) and Cu(II) containing mixed-ligand coordination polymers

In this study, we report the synthesis and structural characterization of two new Co(II) and Cu(II) containing coordination polymers {[Co2(btc)(mbtz)2]·7H2O}n (1), [Cu2(btc)(mbtz)2]n (2) by using the N donor ligand 1,3-bis(1H-1,2,4-triazol-1-ylmethyl)benzene (mbtz) and the O-donor ligand 1,2,4,5-benzenetetracarboxylic acid (H4btc) as the co-linkers. Furthermore, a sonochemical process was used to produce the nanostructures of coordination polymers 1 and 2. Then, we evaluated the anti-viability of nano 1 and 2 on LTEP lung cancer cells. And the Annexin V-FITC/PI staining was performed to detect the apoptosis induced by nano 1 and 2 on LTEP cells. The ROS level in LTEP cells was measured by DCFH-DA assay.