Histopathology of Met mutant lines on the FVB and B6 backgrounds.

Mammary adenocarcinomas were found with a significantly higher proportion in FVB-MetM1248T/L1193V compared to B6-MetM1248T/L1193V mice (p = 2.4×10−6). Hemangiosarcomas developed at a higher incidence in B6-MetY1228C and B6-MetD1226N mice compared to the FVB lines (Y1228C, p = .0005; D1226N, p = .01). *Lymphomas included plasmacytomas and histiocytic sarcomas on the FVB background and lymphoblastic, lymphocytic, histiocytic sarcomas, and follicular center lymphomas on the B6 background. **Sarcomas included a rhabdomyosarcoma and undifferentiated sarcomas on the FVB background and fibrosarcomas, myxomas, leiomyosarcomas, and spindle-like sarcomas on the B6 background.#Animals without any identifiable tumor burden or cause of death are referred to as “nonremarkable”.