RNA-Sequencing of Chronic hypersensitivity pneumonitis compared with Idiopathic Pulmonary Fibrosis and Control Lung

Chronic hypersensitivity pneumonitis (CHP) is caused by an immune response to antigen inhalation and is characterized by variable histopathological and clinical features. A subset of CHP subjects have usual interstitial pneumonia and appear to be clinically similar to subjects with idiopathic pulmonary fibrosis (IPF). However, the molecular relationship between CHP and IPF is not well understood. We report an RNA-seq based transcriptomic analysis for whole lung tissues from CHP, IPF and control subjects. To determine the common and unique molecular features of CHP and IPF, transcriptome analysis of lung samples from CHP (N=82), IPF (N=103), and unaffected controls (N=103) was conducted. Differential gene expression was determined adjusting for sex, race, age and smoking history, and using false discovery rate (FDR) to control for multiple comparisons. >>>Submitter states that raw data are unavailable due to patient privacy concerns<<<