Transcriptome analysis of mesothelial cells induced by intraperitoneal injections of crocidolite in rats

Malignant mesothelioma (MM) is an aggressive tumor strongly associated with asbestos exposure. The granuloma capturing crocidolite contribute to mutagenesis, cell death and regenerative activity. To clarify the biological responses of mesothelial cells after crocidolite exposure, we compared the microarray gene expression profiles of no treatment and crocidolite exposure (1 wks) mesothelial cells induced by intraperitoneal injections.恶性胸膜间皮瘤（Malignant mesothelioma, MM）是一类与石棉暴露高度相关的侵袭性肿瘤。捕获青石棉（crocidolite）的肉芽肿可参与诱变过程、诱导细胞死亡并介导再生活性。为阐明间皮细胞在青石棉暴露后的生物学应答特征，本研究对比了经腹腔注射诱导的未处理组与青石棉暴露1周的间皮细胞的基因芯片表达谱。