Dose fractionation designs of an identical daily dose.

Note: AUC24 may not be identical in drugs with an elimination half-life of ≥4 hours. The discrepancy is due residual drug at the end of the 24 hour period, which is more prominent with a drug of long half-life. One simple way to circumvent the discrepancy is to focus on AUC 0–infinity (total cumulative exposure) instead of AUC 0–24.