DNA methylome analysis of primary prostate cancer and pathologic lymph node metastases in patients with low and high Gleason score

DNA-methylation profiles of primary tumors (PT) and paired synchronous lymph node metastases (LN) from Gleason Score (GS)-6/7a (n=20 LN-positive, n=20 LN-negative) and GS-9/10 patients (LN-positive n=20) after prostatectomy and lymphonodectomy were analyzed. 5 groups were compared: GS-6/7a N0 primary tumors, GS-6/7a N1 primary tumors, GS-6/7a N1 lymph node metastasis, GS-9/10 N1 primary tumors, GS-9/10 N1 lymph node metastasis