Data and code for a preclinical meta-analysis of traditional medicinal plant-derived flavonoids in pulmonary fibrosis with senescence-focused network pharmacology and molecular simulation

This repository contains the de-identified extracted dataset, analysis code, canonical results, figure source data, PRISMA 2020 materials, risk-of-bias files, sensitivity analyses, validation reports and molecular-simulation support files for a preclinical systematic review and meta-analysis of traditional medicinal plant-derived flavonoid monomers in pulmonary fibrosis. The meta-analysis archive includes study-level and arm-level data, reproducible Python scripts, canonical estimates, sensitivity analyses, PRISMA screening outputs, figure source data and reports. The TGFBR1-luteolin archive includes network-pharmacology outputs, molecular docking results, three-replicate molecular-dynamics analysis outputs, MM-GBSA-style per-residue summaries, binding poses, figures, scripts and software environment information. The files support the manuscript entitled “Senescence-related anti-fibrotic potential of traditional medicinal plant-derived flavonoids in pulmonary fibrosis: a preclinical meta-analysis integrating network pharmacology and molecular simulation”.