Supporting data for "Effects of inflammation on the aged periodontium via NF-κB/FOXO3a/c-JUN signalling"

Ageing is widely recognized as a major risk factor for numerous chronic inflammatory diseases. The pro-inflammatory state observed in ageing individuals may serve as a biomarker of the rate of ageing. Elevated concentrations of pro-inflammatory markers in older individuals have been found to be associated with an increased risk of age-related diseases and various chronic conditions. Coinciding with other chronic diseases, periodontal disease increases in prevalence and severity with ageing. The periodontal ligament (PDL) is a key component of the periodontium, and periodontal ligament cells (PDLCs) play a vital role in the process of periodontal remodeling. However, the specific mechanisms that connect inflammation with ageing in the periodontium remain unclear. The aim of this study was to investigate the effect of inflammation on the senescence phenotype and bone metabolism of the aged periodontium and to explore the molecular mechanisms underlying this effect.

老龄化被广泛认为是众多慢性炎症性疾病的主要风险因素。在老年人中观察到的促炎状态可能作为衰老速率的生物标志物。研究发现，老年个体中促炎标志物的浓度升高与年龄相关疾病及多种慢性状况的风险增加相关。与其它慢性疾病相伴，牙周病随着年龄的增长在发病率和严重程度上均有所上升。牙周韧带（PDL）是牙周组织的关键组成部分，牙周韧带细胞（PDLCs）在牙周重塑过程中发挥着至关重要的作用。然而，将炎症与牙周组织衰老相关联的具体机制尚不明确。本研究旨在探讨炎症对老年牙周组织衰老表型和骨代谢的影响，并探究导致此效应的分子机制。