Crystal structure of IDH1 R132H mutant in complex with compound 32
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Crystal structure of IDH1 R132H mutant in complex with compound 32 Descriptor: 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)methyl]amino}-2-methylpyridine-3-carbonitrile, GLYCEROL, Isocitrate dehydrogenase [NADP] cytoplasmic, ... Authors: Toms, A.V, Lin, J. Deposit date: 2019-02-25 Release date: 2019-06-26 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J.Med.Chem., 62, 2019
创建时间：
2019-02-25
