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Bioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells

ChEBI2009-05-27 更新2026-07-21 收录

成人T细胞白血病

HSP90抑制剂药理药效

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-12257 数据链接链接失效反馈

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资源简介：

Bioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells

应用场景：

创建时间：

2009-05-27

转录因子ChIP-seq

成人T细胞白血病

ChIP-seq analysis was performed in an adult T-cell leukemia/lymphoma cell line (TL-Om1) to analyze DNA bindings of TP73 in TL-Om1 cells. Overall design: TL-Om1 cells were crosslinked with formaldehyde

NIAID Data Ecosystem70

Study on the mechanism of action of CD4+ T cells infected with HTLV-1 virus based on RNA sequencing technology

HTLV-1病毒感染

成人T细胞白血病

we discovered a new molecule that can regulate HTLV-1 virus infection, which provides a new direction for the therapeutic research of adult T-cell leukemia.

NIAID Data Ecosystem60

Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells [GenomeWideSNP_6]

化疗耐药机制

HSP90抑制剂药理药效

Inhibition of the HSP90 chaperone results in depletion of many signaling proteins that drive tumorigenesis, such as downstream effectors of KRAS, the most commonly mutated human oncogene. As a consequ

NIAID Data Ecosystem20

DNA demethylating agents and EZH2 inhibitors for Adult T cell leukemia [Illumina]

成人T细胞白血病

甲基化调控基因

Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T-cells caused by human T-cell lymphotropic virus type 1 (HTLV-1). Recently, it has been noted that some epigenome abnormalities inc

NIAID Data Ecosystem60

Bruceantin targets HSP90 to overcome resistance to hormone therapy in castration-resistant prostate cancer

耐药性前列腺癌

HSP90抑制剂药理药效

Here we report the identification of bruceantin as a highly potent inhibitor of HSP90. RNA-seq analysis demonstrated bruceantin inhibits the transcriptional activity of androgen receptor and androgen

NIAID Data Ecosystem30

Bioligical pathways and in vitro anti-proliferative activity of Hsp90 inhibition in adult T cell leukemia cells

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