High fat diet-induced hyperlipidemic stress and redox imbalance in rat: Relevance to aging

Based on this data, we conclude that young rats display more potential to combat HFD-induced oxidative and hyperlipidemic stress compared to aged rats. We hypothesize that a low antioxidant capacity and a high level of reactive oxygen species in aged rats could be responsible for the observed effects. The study strengthens growing scientific opinion in support of an HFD induced oxidative stress, particularly during old age.

基于此数据，我们得出结论：与老年大鼠相比，年轻大鼠在抵抗高脂饮食诱导的氧化应激和血脂异常方面展现出更大的潜力。我们假设，老年大鼠的低抗氧化能力和高活性氧水平可能是造成观察到的效应的原因。该研究进一步巩固了日益增长的科学研究共识，即高脂饮食诱导的氧化应激，尤其在老年时期尤为显著。