Developmental chromatin programs determine oncogenic competence in melanoma [Cut&Run]

We perfomed Cut&Run for ATAD2, MYC and SOX10 in 3xKO ATAD2 dox melanocytes and 3xKO dox melanocytes. We used 10'000 cells per condition and the protocol was performed as in Skene et al., 2018. We could show that, in the 3xKO ATAD2 dox melanocytes, ATAD2, MYC and SOX10 have common targets. Many of those targets belong to a developmental signature typical of the neural crest and to the MAPK pathway. Examination of the target genes of ATAD2, MYC and SOX10 in hPSC-derived melanocytes