A Highly Diastereoselective Decarboxylative Mannich Reaction of β-Keto Acids with Optically Active N-Sulfinyl α-Imino Esters
收藏Figshare2016-02-20 更新2026-04-29 收录
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https://figshare.com/articles/dataset/A_Highly_Diastereoselective_Decarboxylative_Mannich_Reaction_of_Keto_Acids_with_Optically_Active_i_N_i_Sulfinyl_Imino_Esters/2513515
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资源简介：
A range of protected γ-oxo-α-amino esters have been prepared in a highly regio- and stereoselective manner through the decarboxylative Mannich reaction of β-keto acids with optically active N-tert-butanesulfinyl α-imino esters in the presence of 3 mol % La(OTf)3 or 5 mol % Y(OTf)3 at 20 °C. Preliminary mechanistic studies indicate that the reaction proceeds through imine addition followed by decarboxylation.
创建时间：
2016-02-20
