MiRNA-mediated regulation of Bmp2 during pathological calcification
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE135759
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资源简介：
Renal disease is a major risk factor for cardiovascular disease. BMP2 and its downstream effectors are strong implicators of pathological calcificatoin. We profiled miRNAs from Klotho mutant mice and from health mice to determine any potential biomarkers for predicting the progression of pathological calcification through targeting of BMP2 and its downstream effectors. 1908 miRNA levels measured from 19 mice. Klotho homozygotes (Klkl/kl) exhibited the full phenotype with aortic calcification. Control mice with the wild type (Kl+/+) or heterozygous (Kl+/kl) Klotho genotypes were healthy and indistinguishable.
创建时间：
2020-10-29
