RUNX2 and SP7 bind the UCMA gene promoter

Based on mouse studies, RUNX2, presumably associated with CBFB, and SP7 (also known as Osterix or OSX), bind to adjacent RUNX2 and OSX binding sites, respectively, in the promoter of the UCMA gene. RUNX2 and OSX binding sites in the UCMA promoter are evolutionarily conserved. It is not clear whether RUNX2 and SP7 directly physically interact (Lee et al. 2015).

基于对小鼠的研究，RUNX2（据推测与CBFB相关联）以及SP7（亦称Osterix或OSX），分别与UCMA基因启动子区域相邻的RUNX2和OSX结合位点相结合。UCMA基因启动子中的RUNX2和OSX结合位点在进化过程中保持一致。目前尚不清楚RUNX2和SP7是否直接发生物理相互作用（Lee等人，2015年）。