AFM liver tissue data

This dataset consists of 27 tissue samples collected from 7 patients suffering from colorectal or pancreatic cancer metastasis who underwent curative liver resection surgery. Tissue punches were collected from healthy and tumour regions during surgery. Each section was measured using an atomic force microscope (AFM) to extract the elastic modulus of the tissue at multiple sites. Microscope images were captured of the whole sample as well as at each measurement site, allowing for spatial localization of each measurement. In some cases, the section was stained post-hoc with haemotoxylin and eosin (H&E), providing ground-truth validation of tissue pathology.There are two datasets available:1. The full liver tissue dataset (46.4 GB), which for each sample containsRaw and processed AFM measurement data for each measurement site (multiple formats: .csv and .mat for processed data)4X microscopy image of the unstained tissue sample (RGB TIFF)4X microscopy images of each measurement site (RGB TIFFs)Annotated image showing spatially localized measurement sites (RGB TIFF)MATLAB workspaces of the registration results (.mat)20X microscopy image of the post-measurement stained sample (RGB TIFF) (Note: not all samples contain stained images)Predicted whole-sample elastic modulus maps produced by a GAN detailed here (32-bit float TIFF)2. The image patch training dataset (8.84 MB):308 training and 78 validation sets, each containing:- 64 x 64-pixel unstained tissue sample image patches (8-bit grayscale)- 32 x 32-pixel tissue topology maps (32-bit float)- 32 x 32-pixel elastic modulus maps (32-bit float)

本数据集由27份组织样本构成，这些样本来自7名患有结直肠癌或胰腺癌转移的病人，且这些病人在接受了治愈性肝切除术。在手术过程中，从健康组织和肿瘤区域收集了组织活检。每个样本的切片均使用原子力显微镜（AFM）进行测量，以提取组织在不同部位的弹性模量。同时，对整个样本以及每个测量点进行了显微镜成像，以便对每个测量点进行空间定位。在某些情况下，切片在事后用苏木精和伊红（H&E）染色，以提供组织病理学真实情况的验证。数据集包括以下两部分：1. 完整肝脏组织数据集（46.4 GB），其中每个样本包含：- 每个测量点的原始和经过处理的AFM测量数据（多种格式：.csv和.mat格式处理数据）- 未染色组织样本的4倍显微镜图像（RGB TIFF）- 每个测量点的4倍显微镜图像（RGB TIFFs）- 显示空间定位测量点的标注图像（RGB TIFF）- 注册结果的MATLAB工作空间（.mat）- 测量后染色的样本的20倍显微镜图像（RGB TIFF）（注意：并非所有样本都包含染色图像）- 由GAN生成的预测全样本弹性模量图（32位浮点TIFF）2. 图像块训练数据集（8.84 MB），包含：- 308个训练集和78个验证集，每个集包含：- 64 x 64像素未染色组织样本图像块（8位灰度）- 32 x 32像素组织拓扑图（32位浮点）- 32 x 32像素弹性模量图（32位浮点）