CMP-Neu5Ac hydroxylase (Cmah) disruption caused several abnormalities and diseases including hearing loss in old age. However, underling molecular mechanisms that give rise to age-related hearing loss

NIAID Data Ecosystem80

table s2

耳蜗蛋白质组学

活性氧生成

Proteomics data showing up-regulation in some key ROS generation protein levels in the cochlea of Cx30−/− mice at P18

Figshare2020-08-04 更新70

Gene expression in the embryonic endolymphatic sac of E13.5, E14.5, E16.5 and E17.5 Slc26a4Δ/+ and Slc26a4Δ/Δ mice

听觉疾病分子机制

基因表达谱分析

Gene expression was analyzed in endolymphatic sacs of two groups of mice: Slc26a4Δ/Δ and Slc26a4Δ/+ mice. Slc26a4Δ/Δ mice fail to develop hearing and are a model for Enlarged Vestibular Aqueduct and

NIAID Data Ecosystem90

Comprehensive analysis on the signaling pathway of Norrie disease protein (Ndp)

听觉疾病分子机制

Wnt信号通路

Mutations in the gene for Norrie disease protein (Ndp) cause syndromic deafness and blindness. We show that cochlear function in an Ndp knockout (KO) mouse deteriorated with age: at P3-P4, hair cells

NIAID Data Ecosystem70

Original Proteome Sequencing Data of Cochlea Explants

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