Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics [RNA-seq]. Characterizing Neonatal Heart Maturation, Regeneration, and Scar Resolution Using Spatial Transcriptomics [RNA-seq]

We report the transcriptional changes occuring in fibroblasts obtained from mouse hearts subjected to apical resection surgery or sham surgery, compared to unmanipulated controls, at indicated timepoints. Overall design: Cardiac fibroblasts were isoalted 3 days after apical resection surgery or sham surgery performed at postnatal (P) day 2 (regenerative) or 10 (non-regenerative) and subjected to RNA-sequencing to investigate gene changes that correlate with regeneration and fibroblast resolution.