Vesicle-to-nanotube transformation of diyne phospholipid aggregates

The formation of tubular aggregates tends to occur via helical intermediates or from tethered vesicles. However, our collaborators have observed a vesicle-to-nanotube transformation with comparable vesicle and nanotube diameter and with curved membrane pieces as intermediates using cryo-TEM. Using simultaneous USAXS and WAXS during cooling, we want to study this transformation in the bulk together with its cause, chain crystallization, in the unilamellar and multilamellar case.