Citrobacter rodentium strain:ATCC 51459 (DBS100) Transcriptome or Gene expression

Citrobacter rodentium (Cr) is a mouse pathogen that mimics many aspects of enteropathogenic Escherichia coli infections including producing attaching and effacing (A/E) lesions. Host-adapted (HA) Cr cells that are shed at the peak of infection have been reported to be hyperinfective. The exact mechanism underlying this phenomenon has remained elusive since the pathogen loses its HA ‘status’ immediately upon sub-culturing in laboratory media. We sequenced the entire transcriptome of Cr isolated from the feces of infected mice and from media grown Cr, and looked for differentially expressed genes. These results demonstrate that host-adapted Cr has a unique transcriptome that is associated with increased host transmission.

鼠伤寒沙门氏菌（Citrobacter rodentium，简称Cr）是一种模拟鼠源致病性大肠杆菌感染许多方面的病原体，包括产生附着和消除（A/E）损伤。报道指出，在感染高峰期脱落的宿主适应性（HA）Cr细胞具有高度感染性。然而，这一现象背后的确切机制一直难以捉摸，因为病原体在实验室培养基的亚培养过程中立即丧失其宿主适应性‘状态’。我们对从感染小鼠粪便中分离的Cr和从培养基中生长的Cr的全转录组进行了测序，并寻找差异表达基因。这些结果揭示了宿主适应性Cr具有独特的转录组，与增加的宿主传播相关。