Expression data from wild-type and HMGN1 knockout mice injected with N-nitrosodiethylamine

HMGN1 contributes to the shortened latency of liver tumorigenesis by changing a chromatin structure and expression of relevant genes To assess the molecular mechanisms underlying accelerated tumor development in Hmgn1-/- mice, we performed the gene expression profiling of liver cells at early stages. Expression profiles has been compared between Hmgn1+/+ and Hmgn1-/- mice livers at 4 weeks after birth and at 12 weeks after DEN or saline (control) injection at 4 weeks核高迁移率族蛋白1（HMGN1）可通过调控染色质结构及相关基因表达，缩短肝脏肿瘤发生的潜伏期。为解析Hmgn1基因敲除（Hmgn1-/-）小鼠肿瘤发生加速的分子机制，本研究对早期阶段的肝脏细胞进行了基因表达谱分析。我们针对两种基因型小鼠的肝脏组织开展了基因表达谱比较：其一为出生后4周的Hmgn1野生型（Hmgn1+/+）与Hmgn1敲除（Hmgn1-/-）小鼠肝脏；其二为出生后4周经二乙基亚硝胺（DEN）或生理盐水（对照组）注射后12周的上述两种基因型小鼠肝脏。