Colocalisation results for the Tambets et al NMR metabolic trait GWAS study

Main colocalisation results meta_EUR_big_coloc_151025.tsv.gz - table with the main colocalisation results used in the manuscript. The code for generating this table is avaliable from GitHub. meta_EUR_big_coloc_browser_formatted.tsv.gz - version of the main colocalisation table that has been reformatted for the colocalisation browser available at https://elixir.ut.ee/eqtl/nmr-coloc. Column names of the main colocalisation table: PP.H3 - Posterior probability of coloc hypothesis 3: two distinct causal variants PP.H4 - Posterior probability of coloc hypothesis 4: one shared causal variant signal1 - Name of the colocalising trait signal lead1 - Lead variant of the colocalising trait signal signal2 - Name of the metabolic trait signal lead2 - Lead variant of the metabolic trait signal metabolite - Name of the metabolic trait maf2 - Minor allele frequency of the metabolic trait lead variant (lead2) log10p2 - Negative log10 p-value of the metabolic trait lead variant associaiton gene_symbols - Names of three closest genes UKBPPP_ProteinID - Protein ID of the colocalising UKB-PPP pQTL signal signal1_trait - Name of the colocalising trait source - Colocalisation source quant_method - RNA-seq quanatifiction method (for eQTL Catalogue colocalisations only) molecular_trait_id - eQTL Catalogue molecular trait id cluster - Unique identifier for each clolocalisation cluster n_metabolites - Number of distinct metabolic traits belonging to the colocalisation cluster In addition to these main results, we also provide the raw gpu-coloc colocalisation outputs for individual data sources: FinnGen_lbf_coloc.tar.gz FinnGen_abf_coloc.tar.gz eQTL_Catalogue_coloc.tar.gz PANUKBB_coloc.tar.gz Suzuki_Aragam_coloc.tar.gz MVP_coloc.tar.gz INTERVAL_coloc.tar.gz UKBPPP_coloc.tar.gz