Phosphorylated heterodimers of ERBB2 ECD mutants and EGFR bind PLCG1

PLCgamma1 signaling is activated dowsntream of ERBB2 ECD mutants ERBB2 G309A (Bose et al. 2013), ERBB2 G309E (Greulich et al. 2012) and ERBB2 S310F (Greulich et al. 2012), as evidenced by activating phosphorylation of PLCG1. It is assumed that heterodimers of ERBB2 ECD mutants and EGFR, like the wild type heterodimers of ERBB2 and EGFR, bind to PLCG1.

PLCgamma1信号通路在ERBB2 ECD突变体（如Bose等人于2013年报道的ERBB2 G309A，Greulich等人于2012年报道的ERBB2 G309E和ERBB2 S310F）下游被激活，这一现象通过PLCγ1的激活磷酸化得到证实。据此假设，ERBB2 ECD突变体与EGFR形成的异源二聚体，类似于野生型ERBB2与EGFR的异源二聚体，均能与PLCγ1结合。