Palladium-Catalyzed Cascade Assembly of Tricyclic Spiroethers from Diene-Alcohol Precursors

Palladium-catalyzed
carboetherification-Heck reactions to form
tricyclic spiroethers, which are frequently observed as scaffold segments
of various biochemical compounds, from simple diene-alcohols have
been carried out in a cascade fashion. This is the first attempt to
link simple alcohols with diverse, medium-sized spiroether architectures.
The reported synthetic strategy is short and robust and offers rapid
delivery of a broad spectrum of tricyclic spiranoid ethers.