Supplementary Material for: A Case Report of Mixed Acinar-Neuroendocrine Pancreatic Carcinoma (MANEC): A Rare Subtype of Pancreatic Cancer

Introduction: Mixed acinar-neuroendocrine carcinoma (MANEC) is a rare variant of pancreatic carcinoma, the morphology of which shows features of both acinar cell carcinoma and neuroendocrine carcinomas. To date, only approximately 70 cases of MANEC have been reported.
Case Presentation: We report a rare case of a 63-year-old male cirrhotic patient who presented with a pancreatic body/tail mass, which was later confirmed to be a mixed acinar and neuroendocrine carcinoma. He was initiated on neoadjuvant chemotherapy with Folfirinox, but unfortunately died before surgery.
Conclusion: MANEC is a rare sporadic tumor of the pancreas. Further studies on the clinicopathological behavior of MANEC are needed to help better understand the disease and establish standardized management.