Gene expression profiling in dorsolateral prostates of prepubertal and adult Sprague-Dawley rats dosed with Estradiol Benzoate, Estradiol and Testosterone

Using rat prostate disease models that Prins and colleagues have developed (Ho et al., 2006 - PMID: 16740699), the purpose of the study is to identify gene(s) for diagnosing early stage of prostate diseases and monitoring the development of prostate diseases. To identify the genes, we analyzed whole genome expression profiling on the prostate from Sprague-Dawley rats dosed postnatally with estradiol benzoate, estradiol and testosterone at PNDs 30, 100 and 145.本研究采用Prins及其团队构建的大鼠前列腺疾病模型（Ho等，2006，PMID：16740699），旨在筛选可用于前列腺疾病早期诊断及病情进展监测的基因靶标。为筛选该类基因，本研究对出生后第30、100、145天分别接受苯甲酸雌二醇（estradiol benzoate）、雌二醇（estradiol）及睾酮（testosterone）给药的斯普拉格-道利（Sprague-Dawley）大鼠的前列腺组织开展了全基因组表达谱（whole genome expression profiling）分析。