Epigenome-Wide Association Study in multiple system atrophy (MSA). Epigenome-Wide Association Study in multiple system atrophy (MSA)

Genome-wide methylation profiling of DNA extracted from the prefrontal cortex of post-mortem MSA patients (n=41) or normal, healthy controls (CTRLs; n=37). The Illumina Infinium MethylationEPIC BeadChip was used, investigating app. 850,000 CpG sites throughout the genome Overall design: Bisulphite (BS) or oxidative bisulphite (oxBS) converted DNA from 78 samples (41 MSA, 37 CTRL) were hybridized to the Illumina Infinium MethylationEPIC BeadChip.