Structure of PYCR1 complexed with the allosteric inhibitor 2-[(2,6-dichlorophenyl)amino]pyridine-3-sulfonic acid

Structure of PYCR1 complexed with the allosteric inhibitor 2-[(2,6-dichlorophenyl)amino]pyridine-3-sulfonic acid Descriptor: 2-(2,6-dichloroanilino)pyridine-3-sulfonic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ... Authors: Tanner, J.J, Meeks, K.R. Deposit date: 2025-06-07 Release date: 2026-02-04 Last modified: 2026-03-25 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Serendipitous discovery of an allosteric inhibitor binding groove in the proline biosynthetic enzyme pyrroline-5-carboxylate reductase 1. Biochem.J., 483, 2026